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"Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I). It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China used as a cancer treatment in Traditional Chinese Medicine. CPT showed remarkable anticancer activity in preliminary clinical trials but also low solubility and (high) adverse drug reaction. Because of these disadvantages, synthetic and medicinal chemists have developed numerous syntheses of Camptothecin and various derivatives to increase the benefits of the chemical, with good results. Two CPT analogues have been approved and are used in cancer chemotherapy today, topotecan and irinotecan.",""
cPT;SN38;Ampule;10-cPT;Nc 107124;HYDRcAMPTOTHcINE;HYDROXcAMPTOTHcIN;hydroxycamptothci;Irinotcan USP c A;10-HYDRcAMPTOTHcIN
G. Samuelsson (2004); H. Ulukan, P.W. Swaan (2002)
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This page contains information about 10 hydroxy Camptothecin Cas # 19685-09-7 and its Metabolites.
10 hydroxy Camptothecin 10 hydroxy Camptothecin Worldwide Suppliers of 10 hydroxy Camptothecin https://www.clearsynth.com/en/CSO06296.html Metabolites Clearsynth 19685-09-7
Regular price: $500 In stock
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Keywords: Metabolites cPT;SN38;Ampule;10-cPT;Nc 107124;HYDRcAMPTOTHcINE;HYDROXcAMPTOTHcIN;hydroxycamptothci;Irinotcan USP c A;10-HYDRcAMPTOTHcIN CS-O-06296 10 hydroxy Camptothecin Camptothecin 19685-09-7 364.35 C20H16N2O5
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