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"Efinaconazole (trade names Jublia and Clenafin) is a triazole antifungal. It is approved for use in Canada and the USA as a 10% topical solution for the treatment of onychomycosis (fungal infection of the nail). Efinaconazole acts as a 14α-demethylase inhibitor.
In two clinical trials 17.8% and 15.2% of patients using efinaconazole were cured, compared to 3.3% and 5.5% of patients using a placebo.
Efinaconazole is not especially effective, but it is currently the best topical treatment available, with cure rates two or three times better than the next best topical treatment, ciclopirox. It is considered a reasonable option for patients with mild cases, or patients who can not take oral treatment.
In 2014, the U.S. Food and Drug Administration (FDA) approved the New Drug Application (NDA) for Jublia, the \"first topical triazole approved for the treatment of onychomycosis of the toenails.\" According to Valeant Pharmaceuticals International Inc CEO J. Michael Pearson they acquired Jublia through their purchase of Dow Pharmaceutical Sciences in 2008.",""
Efinaconazole is an Azole Antifungal. The chemical classification of efinaconazole is Azoles.
(2R,3R)-2-(2,4-difluorophenyl)-3-(4- methylidenepiperidin-1-yl)-1-(1H-1,2,4-triazol-1- yl)butan-2-ol ;(2R,3R)-2-(2,4-difluorophenyl)-3-(4- methylidenepiperidin-1-yl)-1-(1H-1,2,4-triazol-1- yl)butan-2-ol
Banitt, E.H., et al. 1977. J. Med.chem. 20: 821-826.
We normally respond within 8 hours.
This page contains information about Efinaconazole Cas # 164650-44-6 and its API Standards.
Efinaconazole Efinaconazole Worldwide Suppliers of Efinaconazole https://www.clearsynth.com/en/CSO11195.html API Standards Clearsynth 164650-44-6
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Keywords: API Standards (2R,3R)-2-(2,4-difluorophenyl)-3-(4- methylidenepiperidin-1-yl)-1-(1H-1,2,4-triazol-1- yl)butan-2-ol ;(2R,3R)-2-(2,4-difluorophenyl)-3-(4- methylidenepiperidin-1-yl)-1-(1H-1,2,4-triazol-1- yl)butan-2-ol CS-O-11195 Efinaconazole Efinaconazole 164650-44-6 348.39 C18H22F2N4O
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