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"Canagliflozin (trade name Invokana or Sulisent) is a medication used for the treatment of type 2 diabetes. It is of the gliflozin class or subtype 2 sodium-glucose transport (SGLT-2) inhibitors class.
This mechanism is associated with a low risk of hypoglycaemia (too low blood glucose) compared to sulfonylurea derivatives and insulin. In 2017, the FDA concluded that canagliflozin causes an increased risk of leg and foot amputations. The FDA began requiring a Boxed Warning to be added to the canagliflozin drug labels to describe this risk.
Canagliflozin is an inhibitor of subtype 2 sodium-glucose transport proteins (SGLT2), which is responsible for at least 90% of renal glucose reabsorption (SGLT1 being responsible for the remaining 10%). Blocking this transporter causes up to 119 grams of blood glucose per day to be eliminated through the urine. It was developed by Mitsubishi Tanabe Pharma and is marketed under license by Janssen, a division of Johnson & Johnson.",""
Canagliflozin Glucuronide; Canagliflozin Metabolite M5
Chao, E. et al.: Drug Fut., 36, 351 (2011); Sha, S. et al.: Diab. Obes. Metab., 13, 669 (2011); Kipnes, M.S.:clin. Invest., 1, 145 (2011);
We normally respond within 8 hours.
This page contains information about Canagliflozin-2-Glucuronide Cas # NA and its Glucuronides.
Canagliflozin-2-Glucuronide Canagliflozin-2-Glucuronide Worldwide Suppliers of Canagliflozin-2-Glucuronide https://www.clearsynth.com/en/CSO11225.html Glucuronides Clearsynth NA
Product rating: 9 Canagliflozin-2-Glucuronide based on 20 ratings
Keywords: Glucuronides CS-O-11225 Canagliflozin-2-Glucuronide Canagliflozin NA 620.64 C30H33FO11S
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