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Nilutamide

API Standards
CAT No.
:
CS-O-30698

CAS No.

:

63612-50-0

Molecular Weight

:

317.22

Molecular Formula

:

C12H10F3N3O4

Purity

:

>98%

Long Term Storage

:

RT

Inventory Status:

:

Available for Immediate Shipment
 



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Useful information

"Nilutamide (brand names Nilandron (US), Anandron (CA)) is a synthetic, non-steroidal antiandrogen (NSAA) used in the treatment of advanced-stage (metastatic) prostate cancer. It was developed by Roussel, first introduced in 1987 (in Europe) and was the second NSAA to be marketed, with flutamide preceding it and bicalutamide following it in 1995. It was not introduced until 1996 in the United States.[1] Because most prostate cancer cells rely on activation of the androgen receptor (AR) for growth and survival, nilutamide can slow the progression of the disease and extend life in men with prostate cancer.

Nilutamide shows unique and unfavorable tolerability and toxicity profiles, most importantly a high incidence of interstitial pneumonitis (which can progress to pulmonary fibrosis, a potentially fatal condition), and this has limited its clinical use. From a safety standpoint, bicalutamide is clinically preferred not only over nilutamide (due primarily to its risk of interstitial pneumonitis) but also flutamide (due to its high risk of hepatotoxicity) in choice of NSAA.",""



Product Application Notes

Nilutamide is a synthetic, nonsteroidal agent with antiandrogenic properties. Nilutamide preferentially binds to androgen receptors and blocks androgen receptor activation by testosterone and other androgens; this agent may inhibit androgen-dependent grow



References

O'Donnell, M., et al.: J. Pharmcol. Exp. Ther., 259, 751 (1991), Jones, T., et al.: J. Physiol. Pharmcol., 73, 191 (1995), Kawano, T., et al.: J. Allergyclin. Immunol., 112, 369 (2003),



MSDS



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This page contains information about Nilutamide Cas # 63612-50-0 and its API Standards.

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Keywords

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Related result for 'Nilutamide'

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