6-a-Hydroxy Paclitaxel-D5
| Product Name | 6-a-Hydroxy Paclitaxel-D5 |
|---|---|
| Alternate Names | Paclitaxel Stable Isotopes, Stable Isotopes of Paclitaxel |
| CAT No. | CS-AU-00064 |
| CAS No. | 1315376-90-9 |
| Category | Stable Isotopes |
| Stock | Enquire |
| Mol. Wt. | Not Available |
| Mol. For. | Not Available |
| Hazardous | This is not a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Paclitaxel |
| Therapeutic | Anti-Cancer / Oncology |
| Smileys | CC(O[C@@]1([C@]([C@@H](O)[C@@H]2O)([H])OC1)[C@@]([C@@]2(C3=O)C)([H])[C@@H]([C@@](C4(C)C)(C[C@H](OC([C@H](O)[C@H](C5=CC=CC=C5)NC(C(C([2H])=C6[2H])=C(C([2H])=C6[2H])[2H])=O)=O)C(C)=C4[C@H]3OC(C)=O)O)OC(C7=CC=CC=C7)=O)=O |
| Canonical Smiles | CC1=C2C(C(=O)C3(C(C(C(C2(C)C)(CC1OC(=O)C(C(C4=CC=CC=C4)NC(=O)C5=CC=CC=C5)O)O)OC(=O)C6=CC=CC=C6)C7(COC7C(C3O)O)OC(=O)C)C)OC(=O)C |
| InchIKey | NDCWHEDPSFRTDA-NZSUPHSRSA-N |
| Inchl | InChI=1S/C47H51NO15/c1-24-30(61-43(57)33(51)32(27-16-10-7-11-17-27)48-41(55)28-18-12-8-13-19-28)22-47(58)40(62-42(56)29-20-14-9-15-21-29)36-45(6,38(54)35(60-25(2)49)31(24)44(47,4)5)37(53)34(52)39-46(36,23-59-39)63-26(3)50/h7-21,30,32-37,39-40,51-53,58H,22-23H2,1-6H3,(H,48,55)/t30-,32-,33+,34-,35+,36-,37-,39+,40-,45-,46+,47+/m0/s1/i8D,12D,13D,18D,19D |
| IUPAC | [(1S,2S,3R,4S,7R,8S,9R,10S,12R,15S)-4,12-diacetyloxy-1,8,9-trihydroxy-15-[(2R,3S)-2-hydroxy-3-[(2,3,4,5,6-pentadeuteriobenzoyl)amino]-3-phenylpropanoyl]oxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
6-a-Hydroxy Paclitaxel-D5 is a derivative of Paclitaxel, a natural product extracted from the bark of the Pacific Yew tree. Paclitaxel has been used as an effective chemotherapy agent for various types of cancers such as ovarian, breast, and lung cancer. 6-a-Hydroxy Paclitaxel-D5 is a deuterated analogue of Paclitaxel, where five deuterium atoms are incorporated into the molecule. This modification is done to improve the pharmacokinetic properties of the drug, including increased metabolic stability and decreased toxicity.
The primary mechanism of action of Paclitaxel and its derivatives is the inhibition of microtubule depolymerization, leading to cell cycle arrest and apoptosis. 6-a-Hydroxy Paclitaxel-D5 acts in a similar manner and has been shown to have potent antitumor activity in vitro and in vivo.
The chemical structure of 6-a-Hydroxy Paclitaxel-D5 includes a hydroxyl group attached to the sixth carbon atom of the Paclitaxel molecule. This modification can affect the drug's solubility, stability, and bioavailability. Therefore, proper storage and handling of the drug are essential to maintain its efficacy.
In conclusion, 6-a-Hydroxy Paclitaxel-D5 is a promising chemotherapy agent that has shown significant antitumor activity in preclinical studies. Its chemical modifications have improved its pharmacokinetic properties, making it a potential candidate for clinical trials.
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Related Compounds
Paclitaxel-D5 (Benzoylamine) | Paclitaxel-D5 (Benzoyloxy) |