trans-Abacavir Dihydrochloride

Chemical Name trans-Abacavir Dihydrochloride
Alternate Names Abacavir Impurities, Impurities of Abacavir
CAT No. CS-BI-00051
CAS Registry# 267668-71-3
Category Impurities
Stock IN-Stock
Mol. Wt. 359.25 g/mol
Mol. For. C₁₄H₂₀Cl₂N₆O
Hazardous This is a Hazardous Compound
COA View Sample COA
MSDS View Sample MSDS
Parent API Abacavir
Purity 95%
Therapeutic Antiretroviral / Anti-HIV
Smileys OC[C@H]1C=C[C@H](N2C=NC3=C(NC4CC4)N=C(N)N=C23)C1.[H]Cl.[H]Cl
Canonical Smiles C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)C4CC(C=C4)CO.Cl
InchIKey QXNOPHSMRJNHHG-GNAZCLTHSA-N
Inchl InChI=1S/C14H18N6O.ClH/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21;/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19);1H/t8-,10-;/m0./s1
IUPAC [(1R,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methanol;hydrochloride
Controlled No
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Trans-Abacavir Dihydrochloride is a medication used in the treatment of HIV infection. It is an antiretroviral drug that belongs to the class of nucleoside reverse transcriptase inhibitors (NRTIs). The drug works by inhibiting the activity of reverse transcriptase, an enzyme that is necessary for the replication of HIV. The medication is administered orally in the form of tablets. The recommended dose for adults is 600 mg daily, taken either as a single dose or divided into two doses. The dosage may vary for children, depending on their age and weight. It is important to follow the dosage instructions provided by the healthcare provider. The chemical formula of trans-Abacavir Dihydrochloride is C14H18N6O.2HCl. The drug is a white to off-white crystalline powder that is soluble in water. The active ingredient in the medication is Abacavir, which is a synthetic analogue of guanosine. The drug is rapidly absorbed into the bloodstream, with peak plasma concentrations achieved within 1-2 hours of administration. Trans-Abacavir Dihydrochloride is generally well-tolerated, but may cause some side effects such as nausea, vomiting, diarrhea, headache, and dizziness. Rarely, the medication may cause severe allergic reactions, which can be life-threatening. It is important to seek medical attention immediately if any symptoms of an allergic reaction occur, such as rash, hives, fever, or difficulty breathing. In conclusion, trans-Abacavir Dihydrochloride is an important medication used in the treatment of HIV infection. It works by inhibiting the activity of the reverse transcriptase enzyme, which is necessary for the replication of HIV. The medication is generally safe and well-tolerated, but may cause some side effects. It is important to follow the dosage instructions provided by the healthcare provider and seek medical attention if any symptoms of an allergic reaction occur.

Related Compounds

Abacavir Impurity 4 | Abacavir EP Impurity F | Abacavir 5-(2,3,4-Tri-O-isobytyryl)-ß-D-glucuronic Acid Methyl Ester | Abacavir Nitroso Impurity | Chloro Abacavir | Abacavir EP Impurity A Sulfate Salt | Abacavir impurity N-Oxide | Clorabacavir racemic | O-fomyl Abacavir | ent-abacavir | Abacavir EP Impurity D | Abacavir Lopinavir Methylene Conjugation | Abacavir Impurity B | Cyclopropyldiaminopurine Abacavir |

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