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19-Hydroxybaccatin III is a natural product that is derived from the bark of the Pacific yew tree. It is a taxane and belongs to the class of taxanes, which are known for their anti-cancer properties. Taxanes, including 19-Hydroxybaccatin III, work by inhibiting the growth of cancer cells by disrupting the formation of microtubules, which are essential for cell division.
19-Hydroxybaccatin III is used in the production of the chemotherapy drug paclitaxel, which is used in the treatment of various types of cancer, including breast, ovarian, and lung cancer. Paclitaxel is a highly effective chemotherapy drug that has been shown to improve the survival rates of cancer patients. The use of 19-Hydroxybaccatin III in the production of paclitaxel has significantly increased the availability and accessibility of the drug.
Chemically, 19-Hydroxybaccatin III is a diterpenoid with a molecular weight of 854.05 g/mol. It has a white to off-white crystalline appearance and is soluble in organic solvents such as methanol and ethanol. Its chemical structure contains a taxane ring system, a hydroxyl group, and an ester group. The synthesis of 19-Hydroxybaccatin III is a complex process that involves the extraction of the compound from the yew tree bark and subsequent purification and modification to produce paclitaxel.
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