6-α-Methyl-Cortisol D4

6-α-Methyl-Cortisol D4, also known as 6-alpha-Methyl-11-beta,17-alpha,21-trihydroxy-pregn-4-ene-3,20-dione D4, is a stable isotope-labeled analog of the naturally occurring steroid hormone cortisol. It is commonly used as an analytical standard for mass spectrometry-based assays and research studies. Cortisol is a crucial hormone secreted by the adrenal gland in response to stress, and it plays a vital role in regulating numerous physiological functions in the body, including glucose metabolism, immune response, and cardiovascular function. 6-α-Methyl-Cortisol D4 is often used as an internal standard in cortisol quantification assays, where it provides accurate and precise measurements of cortisol levels in biological samples, including blood, urine, saliva, and cerebrospinal fluid. The chemical structure of 6-α-Methyl-Cortisol D4 is identical to that of cortisol, except for the presence of four deuterium atoms, which serve as stable isotopic labels. These labels help researchers to distinguish between endogenous cortisol and the internal standard during mass spectrometry-based analysis, thereby improving the accuracy and precision of cortisol measurements. In conclusion, 6-α-Methyl-Cortisol D4 is a useful analytical standard for cortisol quantification assays and research studies, and its stable isotopic labels provide accurate and precise measurements of cortisol levels in biological samples.