Chemical Properties: Phenyl-D5-boronic acid

Phenyl-D5-boronic acid is a deuterated form of phenylboronic acid, which is widely used in organic synthesis as a reagent for the formation of carbon-carbon bonds. The compound has the molecular formula C6D5B(OH)2, with a molecular weight of 140.93 g/mol. The deuterated form, Phenyl-D5-boronic acid has a purity of at least 98% and is a white crystalline powder. Phenyl-D5-boronic acid is commonly used as a reagent for Suzuki coupling reactions, which involve the coupling of an arylboronic acid with an aryl halide in the presence of a palladium catalyst. This coupling reaction is widely used in pharmaceutical, agrochemical, and materials science research, where it is used to synthesize complex organic molecules. Phenyl-D5-boronic acid is also used in the synthesis of biologically active compounds, such as enzyme inhibitors, receptor antagonists, and anticancer agents. The deuterated form of phenylboronic acid is used in research to study the mechanism of enzyme-catalyzed reactions, where it acts as a probe to detect the formation of boronic acid esters. In conclusion, Phenyl-D5-boronic acid is a valuable reagent in organic synthesis, particularly in the formation of carbon-carbon bonds. Its use in the synthesis of biologically active compounds and in enzyme-catalyzed reactions makes it a versatile compound in medicinal chemistry research.