11-Deoxycortisol-2,3,4-13C3

11-Deoxycortisol-2,3,4-13C3 is a stable isotope-labeled analog of 11-deoxycortisol, a steroid hormone produced in the adrenal glands. This compound is commonly used in research and clinical settings as a tracer molecule to study the synthesis and metabolism of cortisol and other steroid hormones. One of the main uses of 11-Deoxycortisol-2,3,4-13C3 is in studies of the hypothalamic-pituitary-adrenal (HPA) axis, which is a complex system of signaling pathways that regulates stress responses and other physiological processes. By administering this compound to animal or human subjects, researchers can track its uptake, conversion, and elimination in various tissues and organs, providing valuable insights into the dynamics of HPA axis activity. In addition to its research applications, 11-Deoxycortisol-2,3,4-13C3 also has potential clinical uses. For example, it could be used as a diagnostic tool for disorders of the HPA axis, such as Addison's disease or Cushing's syndrome. It could also be used to monitor the effectiveness of treatments for these conditions, or to assess the impact of stress on cortisol synthesis and metabolism. Chemically, 11-Deoxycortisol-2,3,4-13C3 is a derivative of the natural steroid hormone 11-deoxycortisol, in which three carbon atoms are replaced with stable isotopes of carbon-13. This modification does not significantly alter the chemical or biological properties of the molecule, but it allows for precise tracking of its movement and transformation in vivo.