8,9-Dehydro-17b-estradiol 16,16,17-d3

8,9-Dehydro-17?-estradiol-16,16,17-d3, also known as DHE, is a synthetic estrogen hormone used in scientific research and medical applications. This compound is a dehydrogenated derivative of estradiol, a naturally occurring estrogen hormone in females. DHE is used in research as a tracer for studying the metabolism of estrogen hormones in the body. It is also used in medical applications such as hormone replacement therapy for menopausal women and in the treatment of breast cancer. Chemically, DHE is a steroidal compound that contains three deuterium atoms in its structure, which make it useful for isotope labeling studies. It has a molecular formula of C18H17D3O2 and a molecular weight of 285.37 g/mol. DHE is synthesized from estradiol and undergoes a dehydrogenation reaction to remove the hydrogen atoms from the C8 and C9 positions. DHE binds to estrogen receptors in the body, which can have both estrogenic and anti-estrogenic effects depending on the tissue. It is metabolized in the liver and excreted in urine. While DHE has potential medical applications, it can also have side effects such as increased risk of blood clots, stroke, and breast cancer. Therefore, its use must be carefully monitored and prescribed by a healthcare professional.