16alpha-Hydroxy-17beta-estradiol-2,4-d2

16?-Hydroxy-17?-estradiol-2,4-d2 is a synthetic estrogen derivative used in research and medical applications. It is a deuterated form of 16?-Hydroxy-17?-estradiol, which means that two hydrogen atoms in the molecule have been replaced with deuterium atoms. This modification allows researchers to track the behavior of the molecule more precisely using mass spectrometry. In research, 16?-Hydroxy-17?-estradiol-2,4-d2 is used as a tracer molecule to study the metabolism and pharmacokinetics of estrogen compounds in vivo. It can also be used to measure estrogen levels in biological samples such as blood or urine. In medical applications, 16?-Hydroxy-17?-estradiol-2,4-d2 has been investigated as a potential treatment for conditions such as breast cancer and osteoporosis. It has been shown to have anti-tumor properties and can inhibit the growth of breast cancer cells in vitro. The chemical information of 16?-Hydroxy-17?-estradiol-2,4-d2 includes its molecular formula C18H19D2O3, molecular weight of 297.37 g/mol, and a melting point of 214-217 °C. Its structure is similar to that of natural estradiol, with an additional hydroxyl group at the 16th carbon position. This modification alters the molecule's binding affinity to estrogen receptors and can affect its pharmacological properties.