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(±)-Felodipine-d3 (2,3-dichlorophenyl-d3) is a deuterated analogue of the calcium channel blocker, felodipine. Calcium channel blockers are a class of drugs used to treat hypertension (high blood pressure) and angina (chest pain).
Felodipine-d3 works by inhibiting the influx of calcium ions into smooth muscle cells, resulting in relaxation of the blood vessels and decreased blood pressure. The deuterium substitution in this compound allows for precise measurement and tracking of its pharmacokinetics (how the drug moves through the body) and pharmacodynamics (how it affects the body).
Felodipine-d3 is primarily used in research and development studies, particularly in drug metabolism and pharmacokinetic studies. It is also used in clinical trials to determine the efficacy and safety of felodipine and other calcium channel blockers in treating hypertension and angina.
The chemical formula of (±)-Felodipine-d3 (2,3-dichlorophenyl-d3) is C18D3Cl2NO4, and its molecular weight is 375.25 g/mol. The compound is a white to off-white crystalline powder that is sparingly soluble in water and soluble in organic solvents such as methanol, ethanol, and acetone. It is stable under normal storage conditions and has a shelf life of at least two years.
In conclusion, (±)-Felodipine-d3 (2,3-dichlorophenyl-d3) is a useful tool for studying the pharmacokinetics and pharmacodynamics of felodipine and other calcium channel blockers. Its deuterium substitution allows for precise measurement and tracking of its movement through the body, making it a valuable asset in drug development and clinical trials.
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