(±)-Amlodipine-d4 Maleate (2-chlorophenyl-d4)

(±)-Amlodipine-d4 Maleate (2-chlorophenyl-d4) is a deuterated version of Amlodipine Maleate, a calcium channel blocker used for the treatment of hypertension and angina. The deuterium substitution in this compound is used in pharmacokinetic studies to identify and quantify the metabolic fate of the drug in vivo. The chemical formula of (±)-Amlodipine-d4 Maleate (2-chlorophenyl-d4) is C20H22D4ClN3O6, and its molecular weight is 455.98 g/mol. It is a crystalline solid that is soluble in water, ethanol, and methanol. The compound is stable under normal conditions of use and storage. The pharmacological action of (±)-Amlodipine-d4 Maleate (2-chlorophenyl-d4) is due to its ability to selectively inhibit the influx of calcium ions into vascular smooth muscle cells and cardiac muscle cells. This results in relaxation of the arterial and venous smooth muscle, leading to a decrease in peripheral vascular resistance and a reduction in blood pressure. The recommended dosage of (±)-Amlodipine-d4 Maleate (2-chlorophenyl-d4) is dependent on the patient's age, weight, and medical history. It is generally taken orally once daily, with or without food. The drug should not be taken in combination with grapefruit juice or other medications that may interact with its metabolism. In conclusion, (±)-Amlodipine-d4 Maleate (2-chlorophenyl-d4) is a useful tool for pharmacokinetic studies of Amlodipine Maleate. Its chemical properties and pharmacological action make it a safe and effective treatment for hypertension and angina.