(±)-Voriconazole-d3 (difluorophenyl-d3)

(±)-Voriconazole-d3 (difluorophenyl-d3) is a deuterated form of the antifungal medication Voriconazole. This compound is used for research purposes and is primarily utilized in studies aimed at understanding the metabolism and pharmacokinetics of Voriconazole in vivo. Voriconazole is a triazole antifungal medication that is used to treat various fungal infections, including aspergillosis and candidiasis. It works by inhibiting the synthesis of ergosterol, a component of fungal cell membranes. In the deuterated form of Voriconazole, three hydrogen atoms on the difluorophenyl ring are replaced with deuterium atoms. This subtle change in molecular structure allows researchers to track the metabolism and distribution of Voriconazole in vivo using mass spectrometry techniques. Chemically, (±)-Voriconazole-d3 (difluorophenyl-d3) has the molecular formula C16H9D3F2N5O and a molecular weight of 337.33 g/mol. It is a white to off-white crystalline powder that is sparingly soluble in water. The deuterated compound is stable under normal laboratory conditions and can be stored for extended periods without degradation. In conclusion, (±)-Voriconazole-d3 (difluorophenyl-d3) is a useful tool for studying the pharmacokinetics and metabolism of Voriconazole. Its deuterated structure allows for precise tracking of the compound in vivo, making it a valuable resource for researchers seeking to better understand the mechanisms of action of this important antifungal medication.