BIMT 17
| Product Name | BIMT 17 |
|---|---|
| CAT No. | CS-CW-00091 |
| CAS No. | 167933-07-5 |
| Category | Impurities |
| Stock | IN-Stock |
| Mol. Wt. | 390.40 g/mol |
| Mol. For. | C₂₀H₂₁F₃N₄O |
| Hazardous | This is not a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Canonical Smiles | C1CN(CCN1CCN2C3=CC=CC=C3NC2=O)C4=CC=CC(=C4)C(F)(F)F |
| InchIKey | PPRRDFIXUUSXRA-UHFFFAOYSA-N |
| Inchl | InChI=1S/C20H21F3N4O/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12-26)10-13-27-18-7-2-1-6-17(18)24-19(27)28/h1-7,14H,8-13H2,(H,24,28) |
| IUPAC | 3-[2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]-1H-benzimidazol-2-one |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
BIMT 17, also known as Bisindolylmaleimide VIII, is a synthetic compound that has been widely used in biomedical research for its ability to inhibit protein kinase C (PKC) activity. PKC is a family of enzymes that play a critical role in a variety of cellular processes, including cell growth, differentiation, and apoptosis. By inhibiting PKC, BIMT 17 has shown potential as a therapeutic agent for various diseases, including cancer, inflammatory disorders, and cardiovascular diseases.
BIMT 17 works by binding to the ATP-binding site of PKC, thus preventing its activation and downstream signaling. As a result, BIMT 17 has been shown to induce apoptosis in cancer cells, reduce inflammation in various animal models, and improve cardiac function in animal models of heart failure.
Chemically, BIMT 17 is a bisindolylmaleimide derivative, which means it contains two indole rings and a maleimide group. It is a white to off-white powder with a molecular weight of 536.61 g/mol. BIMT 17 is soluble in dimethyl sulfoxide (DMSO) and ethanol and has a melting point of 258-260°C.
In conclusion, BIMT 17 is a potent PKC inhibitor with potential therapeutic applications in various diseases. Its chemical properties and mechanism of action make it an attractive target for drug development, and further research is needed to fully understand its therapeutic potential.
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