Adefovir D4
| Chemical Name | Adefovir D4 |
|---|---|
| Alternate Names | Adefovir Stable Isotopes, Stable Isotopes of Adefovir |
| CAT No. | CS-CX-00055 |
| CAS Registry# | 1190021-70-5 |
| Category | Stable Isotopes |
| Stock | Enquire |
| Mol. Wt. | Not Available |
| Mol. For. | Not Available |
| Hazardous | This is not a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Adefovir |
| Smileys | O=[P](O)(O)COC([2H])([2H])C([2H])([2H])N1C2=NC=NC(N)=C2N=C1 |
| Canonical Smiles | C1=NC(=C2C(=N1)N(C=N2)CCOCP(=O)(O)O)N |
| InchIKey | SUPKOOSCJHTBAH-LNLMKGTHSA-N |
| Inchl | InChI=1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16)/i1D2,2D2 |
| IUPAC | [2-(6-aminopurin-9-yl)-1,1,2,2-tetradeuterioethoxy]methylphosphonic acid |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
Adefovir D4 is a deuterated version of the drug adefovir dipivoxil, which is used to treat chronic hepatitis B infections. Adefovir D4 is a nucleotide analogue that works by inhibiting the reverse transcriptase enzyme, which is essential for the replication of the hepatitis B virus. This drug is administered orally in the form of a tablet.
The chemical structure of Adefovir D4 is similar to that of the natural nucleotide adenosine, with the addition of a phosphonate group. The deuterated version of the drug contains four deuterium atoms, which are heavier isotopes of hydrogen. This modification improves the pharmacokinetics of the drug, making it more stable and less susceptible to degradation.
Adefovir D4 is metabolized in the liver and excreted in the urine. It has a half-life of approximately ten hours. The recommended dose of Adefovir D4 is 10mg once daily, taken with or without food.
Like all medications, Adefovir D4 may cause side effects, including nausea, vomiting, diarrhea, headache, and fatigue. Patients with kidney problems may experience a decrease in kidney function while taking Adefovir D4.
In conclusion, Adefovir D4 is a nucleotide analogue used to treat chronic hepatitis B infections. Its chemical structure is similar to that of adenosine, with the addition of a phosphonate group. The deuterated version of the drug is more stable and has improved pharmacokinetics. Adefovir D4 is metabolized in the liver and excreted in the urine. Its recommended dose is 10mg once daily, and it may cause side effects such as nausea, vomiting, and diarrhea.
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Related Compounds
Adefovir-d4 Phosphate Triethylamine Salt | Adefovir-d4 Diphosphate Triethylamine Salt | Adefovir-d4 Diethyl Ester |