Afatinib D6
| Chemical Name | Afatinib D6 |
|---|---|
| Alternate Names | Afatinib Stable Isotopes, Stable Isotopes of Afatinib |
| CAT No. | CS-CX-00057 |
| CAS Registry# | 1313874-96-2 |
| Category | Stable Isotopes |
| Stock | IN-Stock |
| Mol. Wt. | 491.98 g/mol |
| Mol. For. | C₂₄H₁₉D₆ClFN₅O₃ |
| Hazardous | This is not a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Afatinib |
| Purity | 95% |
| Therapeutic | Anti-Cancer / Oncology |
| Smileys | ClC1=C(F)C=CC(NC2=NC=NC3=C2C=C(NC(/C=C/CN(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)C(O[C@H]4CCOC4)=C3)=C1 |
| Canonical Smiles | CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4 |
| InchIKey | ULXXDDBFHOBEHA-VCXSEIMGSA-N |
| Inchl | InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1/i1D3,2D3 |
| IUPAC | (E)-4-[bis(trideuteriomethyl)amino]-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]but-2-enamide |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
Afatinib D6 is a deuterated analog of afatinib, which is a selective inhibitor of the epidermal growth factor receptor (EGFR) family of tyrosine kinases. The deuterium atom in Afatinib D6 replaces one of the hydrogen atoms in the original afatinib molecule, making it useful as a reference standard for drug metabolism studies.
Afatinib D6 is most commonly used in research studies to determine its pharmacokinetics and metabolism in humans. It is also used in preclinical studies to investigate the mechanisms of action of afatinib and to develop new therapeutic strategies for cancer treatment.
The chemical formula of Afatinib D6 is C24H18D6ClFN4O3, and its molecular weight is 490.99 g/mol. It is a white to off-white crystalline powder that is soluble in water, ethanol, and dimethyl sulfoxide.
Afatinib D6 is a potent inhibitor of EGFR and HER2 tyrosine kinases, which are overexpressed in various types of cancer, including non-small cell lung cancer, breast cancer, and head and neck squamous cell carcinoma. By blocking the activity of these kinases, Afatinib D6 can inhibit cancer cell growth and induce apoptosis, leading to tumor shrinkage and improved patient outcomes.
In conclusion, Afatinib D6 is a valuable tool for investigating the pharmacokinetics and metabolism of afatinib, and for developing new cancer therapies targeting EGFR and HER2 kinases.
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Related Compounds
Afatinib 13C6 | Afatinib D4 |