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Amlodipine D4
| Chemical Name | Amlodipine D4 |
|---|---|
| CAT No. | CS-CX-00109 |
| CAS No. | 1185246-14-3 |
| Status | Available for Immediate Dispatch |
| Category | Stable Isotopes |
| Mol. Wt. | 412.90 mol/g |
| Mol. For. | C₂₀H₂₁D₄ClN₂O₅ |
| Hazardous | This is a Hazardous Compound |
| COA | View Sample COA |
Additional Information
| Packing | Product will be supplied in Vials, in certain conditions we also use 'Septa Vials' |
|---|---|
| Controlled | No |
| Parent API | Amlodipine |
| Smileys | CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN |
| Canonical Smiles | CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN |
| InchIKey | HTIQEAQVCYTUBX-YQUBHJMPSA-N |
| Inchl | InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3/i9D2,10D2 |
| IUPAC | 3-O-ethyl 5-O-methyl 2-[(2-amino-1,1,2,2-tetradeuterioethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| Hazardous | Yes |
Usage and description
Amlodipine D4 is a deuterated form of amlodipine, a commonly used medication for the treatment of hypertension and angina. Amlodipine D4 has the same chemical structure as amlodipine, but with four deuterium atoms replacing four hydrogen atoms. This modification is done for research purposes, as it allows for more accurate analysis of drug metabolism and pharmacokinetics.
Amlodipine D4 works by inhibiting the influx of calcium ions into smooth muscle cells, leading to vasodilation and relaxation of the blood vessels. This results in a decrease in blood pressure and improved blood flow to the heart. Amlodipine D4 has a long half-life of approximately 30-50 hours, allowing for once-daily dosing.
Amlodipine D4 is typically administered orally in tablet form and is available in various strengths. The dosing regimen will depend on the patient's age, medical history, and the severity of their condition. Amlodipine D4 is generally well-tolerated, with common side effects including dizziness, headache, and swelling in the ankles and feet.
In conclusion, Amlodipine D4 is a deuterated form of amlodipine that is used for research purposes to better understand the pharmacokinetics and metabolism of the drug. It works by inhibiting calcium influx, leading to vasodilation and a decrease in blood pressure. Amlodipine D4 is typically administered orally and is well-tolerated, with common side effects including dizziness and headache.
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