Apatinib D8
| Product Name | Apatinib D8 |
|---|---|
| CAT No. | CS-CX-00125 |
| CAS No. | 2468771-43-7 |
| Category | Stable Isotopes |
| Stock | IN-Stock |
| Mol. Wt. | 405.52 g/mol |
| Mol. For. | C24H15D8N5O |
| Hazardous | This is a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Purity | 95% |
| Therapeutic | Anti-Cancer / Oncology |
| Smileys | O=C(C1=CC=CN=C1NCC2=CC=NC=C2)NC3=CC=C(C4(C#N)C([2H])([2H])C([2H])([2H])C([2H])([2H])C4([2H])[2H])C=C3 |
| Canonical Smiles | C1CCC(C1)(C#N)C2=CC=C(C=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4 |
| InchIKey | WPEWQEMJFLWMLV-UHFFFAOYSA-N |
| Inchl | InChI=1S/C24H23N5O/c25-17-24(11-1-2-12-24)19-5-7-20(8-6-19)29-23(30)21-4-3-13-27-22(21)28-16-18-9-14-26-15-10-18/h3-10,13-15H,1-2,11-12,16H2,(H,27,28)(H,29,30) |
| IUPAC | N-[4-(1-cyanocyclopentyl)phenyl]-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
Apatinib D8 is a deuterated form of Apatinib, a tyrosine kinase inhibitor used in the treatment of advanced gastric cancer and other solid tumors. It is an orally administered small molecule drug designed to selectively inhibit the vascular endothelial growth factor receptor-2 (VEGFR-2) signaling pathway. The drug has shown promising results in clinical trials, demonstrating its efficacy in treating various types of cancers.
Apatinib D8 is a white to off-white powder that is moderately soluble in water and ethanol. Its chemical formula is C24H23D8N5O3, and its molecular weight is 461.59 g/mol. The deuterated form of Apatinib has a higher mass than its non-deuterated counterpart, which is useful in pharmacokinetic studies for determining drug absorption, distribution, metabolism, and excretion.
The drug works by blocking the VEGFR-2 pathway, which is involved in tumor angiogenesis, the process by which new blood vessels are formed to supply oxygen and nutrients to cancer cells. By inhibiting this pathway, Apatinib D8 can prevent the growth and spread of cancer cells, leading to tumor shrinkage and improved patient outcomes.
In conclusion, Apatinib D8 is a promising drug in the fight against cancer. Its unique chemical properties and mechanism of action make it a valuable tool for researchers and clinicians in the ongoing battle against this deadly disease.
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