(2-Hydroxypropyl)-gamma-cyclodextrin

(2-Hydroxypropyl)-gamma-cyclodextrin, also known as HP-γ-CD, is a cyclic molecule that belongs to the family of cyclodextrins. It is widely used in pharmaceutical, cosmetic, and food industries due to its unique chemical properties. HP-γ-CD has a hydrophilic outer shell and a hydrophobic inner cavity, which makes it an excellent solubilizer, stabilizer, and encapsulating agent for hydrophobic compounds. It can form inclusion complexes with a wide range of guest molecules, including drugs, flavors, fragrances, and vitamins. These complexes can enhance the solubility, bioavailability, and stability of the guest molecules, and also protect them from degradation and oxidation. HP-γ-CD is a safe and biocompatible substance that has been approved by the FDA as a food additive and excipient for drug formulations. It has low toxicity, low immunogenicity, and low interference with biological functions. It can be administered orally, topically, or parenterally, depending on the application. The chemical structure of HP-γ-CD is composed of eight glucose units that are linked by α-1,4 glycosidic bonds. The hydroxypropyl substituents are attached to the hydroxyl groups of the glucose units through ether linkages. The degree of substitution (DS) of HP-γ-CD can vary from 1 to 15, depending on the manufacturing process and the intended use. The DS affects the size, shape, and solubility of the HP-γ-CD molecule, as well as the strength and selectivity of the inclusion complexation.