Desethylchloroquine diphosphate salt 13C6

[13C6]-Desethylchloroquine diphosphate salt is a labeled compound used in pharmacokinetic studies to determine the distribution and elimination of chloroquine, a drug commonly used to treat malaria. The compound is synthesized by replacing six carbon atoms in the molecular structure of desethylchloroquine with the stable isotope of carbon, ^13C. This labeling allows for the compound to be tracked and measured in biological samples using mass spectrometry. The diphosphate salt form of the compound is used for stability and solubility purposes. The compound is administered orally and is rapidly absorbed into the bloodstream. It is distributed throughout the body, accumulating in tissues such as the liver, lungs, and spleen, where it exerts its antimalarial activity by inhibiting the growth of the parasite. The elimination of [13C6]-Desethylchloroquine diphosphate salt is primarily through the liver, where it undergoes metabolism and is excreted in the bile. The compound has a half-life of approximately 22 days in the body, making it a suitable candidate for long-term pharmacokinetic studies. Overall, [13C6]-Desethylchloroquine diphosphate salt is a valuable tool for understanding the pharmacokinetics of chloroquine and its effects on the body. Its use in research can lead to the development of more effective treatments for malaria and other parasitic diseases.