[13C6]-Tobramycin

[13C6]-Tobramycin is a derivative of the antibiotic drug tobramycin, which is commonly used in the treatment of bacterial infections. The added isotopic label of [13C6] in [13C6]-Tobramycin refers to the six carbon atoms in the molecule that have been replaced with the stable isotope carbon-13. This isotopic labeling of the drug is useful in pharmacokinetic studies, where it can be used to track the drug's distribution and metabolism in the body. The chemical structure of [13C6]-Tobramycin is similar to that of tobramycin, with the addition of the isotopic label. The drug works by binding to bacterial ribosomes, which are responsible for protein synthesis in the cell, and preventing them from functioning properly. This leads to the inhibition of bacterial growth and eventual death of the microorganism. [13C6]-Tobramycin is administered intravenously or via inhalation and is mainly used in the treatment of respiratory tract infections, including those caused by Pseudomonas aeruginosa. It is also used in the treatment of septicemia, bone and joint infections, and skin and soft tissue infections. The pharmacokinetics of [13C6]-Tobramycin have been studied extensively in animal models and in humans, and the drug has been shown to be well-tolerated with minimal side effects. It has a half-life of approximately 2-3 hours and is excreted primarily through the kidneys.