Baclofen 13C6

[13C6]-Baclofen is a labeled form of Baclofen, a medication that is used to treat muscle spasms and stiffness in people with multiple sclerosis, spinal cord injuries, or other conditions affecting the nervous system. The labeling of [13C6]-Baclofen means that six of the carbon atoms in the molecule have been replaced with a heavier isotope of carbon, which allows for more precise tracking of the drug's absorption, distribution, metabolism, and elimination in the body. [13C6]-Baclofen is commonly used in pharmacokinetic and pharmacodynamic studies, where it is administered to subjects and then measured in blood, urine, or other biological fluids to determine how it is processed by the body and how it affects the target receptors in the brain and spinal cord. The labeled form of the drug is particularly useful in studies that require high sensitivity and accuracy, such as those investigating drug-drug interactions, individual variability in drug response, or the effects of different dosing regimens. In terms of chemical information, [13C6]-Baclofen has a molecular formula of C10H10ClNO2, and a molecular weight of 213.64 g/mol. It is a white crystalline powder that is soluble in water and ethanol, and has a melting point of 206-207°C. The drug works by binding to gamma-aminobutyric acid (GABA) receptors in the brain and spinal cord, which helps to reduce the activity of certain neurons and thereby alleviate muscle spasticity and rigidity. Overall, [13C6]-Baclofen is a valuable tool for researchers and clinicians alike, as it allows for more precise and reliable assessments of the drug's pharmacology and therapeutic effects.