[13C4]-Sacubitril sodium salt

[13C4]-Sacubitril sodium salt is a stable isotope labeled version of Sacubitril, a prodrug that is metabolized into the active component, Sacubitrilat. Sacubitrilat is an angiotensin receptor-neprilysin inhibitor (ARNI) that is used in the treatment of heart failure with reduced ejection fraction. It works by inhibiting the breakdown of natriuretic peptides, which are hormones that play a role in regulating blood pressure and fluid balance in the body. By inhibiting their breakdown, Sacubitrilat increases the levels of these peptides, ultimately resulting in vasodilation and improved cardiac function. [13C4]-Sacubitril sodium salt is used in pharmacokinetic and pharmacodynamic studies to track the metabolism and distribution of Sacubitril in the body. The stable isotope labeling allows for accurate and precise analysis of the drug's pharmacokinetics, allowing researchers to better understand how the drug is processed and distributed in the body. This information can be used to optimize dosing regimens and to identify potential drug-drug interactions. Chemically, [13C4]-Sacubitril sodium salt is a white to off-white powder that is soluble in water and methanol. Its molecular formula is C24H28N2NaO6 and it has a molecular weight of 472.47 g/mol. It is stable under normal conditions and should be stored at -20°C. Its chemical properties make it an ideal tool for pharmacological research and drug development.