Amlodipine benzenesulfonate, racemic mixture 13C

[13C]-Amlodipine benzenesulfonate is a racemic mixture of the drug Amlodipine, which is widely used as a calcium channel blocker in the treatment of hypertension and angina. The compound contains a stable isotope of carbon, carbon-13, which allows for its use in metabolic studies and drug development research. The chemical structure of [13C]-Amlodipine benzenesulfonate consists of a dihydropyridine ring system, which is responsible for its calcium channel blocking activity, and a benzene ring attached to a sulfonate group. The racemic mixture contains equal amounts of the S- and R-enantiomers of Amlodipine. The pharmacological effects of [13C]-Amlodipine benzenesulfonate are similar to those of Amlodipine, which include relaxation of vascular smooth muscle and reduction of blood pressure. The compound is metabolized extensively in the liver, primarily by the cytochrome P450 3A4 enzyme system, and excreted in the urine. The use of [13C]-Amlodipine benzenesulfonate in metabolic studies allows for the measurement of drug absorption, distribution, metabolism, and elimination in humans and animals. This information is critical in drug development research, as it can help to identify potential drug interactions, optimize dosing regimens, and improve the safety and efficacy of the drug. Overall, [13C]-Amlodipine benzenesulfonate is a useful tool for researchers and clinicians in the field of cardiovascular medicine, allowing for a better understanding of the pharmacology and metabolism of Amlodipine, and aiding in the development of new and improved treatments for hypertension and angina.