Lisinopril 13C5,15N

[13C5,15N]-Lisinopril is a labeled form of the antihypertensive drug Lisinopril. It is synthesized using stable isotopes of carbon and nitrogen, namely carbon-13 and nitrogen-15. The labeling is done for various reasons such as tracking the metabolism of the drug in vivo or for use in NMR and mass spectrometry. Lisinopril is a medication used to treat hypertension, heart failure, and to improve survival after a heart attack. It belongs to a class of drugs called ACE inhibitors, which work by blocking the action of an enzyme that causes the blood vessels to narrow, leading to an increase in blood pressure. [13C5,15N]-Lisinopril works in the same way as the unlabeled Lisinopril. It is administered orally and is rapidly absorbed, with peak plasma concentrations reached within 7 hours. The drug is metabolized in the liver, and the metabolites are excreted in the urine. The labeled form of Lisinopril is used in pharmacokinetic studies to track the metabolism and distribution of Lisinopril in the human body. It is also used in NMR and mass spectrometry techniques to identify the drug and its metabolites in biological samples. In conclusion, [13C5,15N]-Lisinopril is a labeled form of the antihypertensive drug Lisinopril, used for pharmacokinetic studies and in NMR and mass spectrometry techniques. It is identical in its chemical and pharmacological properties to the unlabeled Lisinopril.