Clopidogrel hydrogensulfate 13C6

[13C6]-Clopidogrel hydrogensulfate is a stable isotope-labeled variant of the antiplatelet medication Clopidogrel hydrogensulfate. This compound is primarily used in pharmacokinetic and metabolic studies to investigate the absorption, distribution, metabolism, and excretion of Clopidogrel hydrogensulfate within the human body. Clopidogrel hydrogensulfate is a prodrug, meaning it is inactive until it is metabolized in the liver into its active form. This process involves the cytochrome P450 system, specifically the CYP2C19 enzyme. By incorporating six carbon-13 isotopes into the molecular structure of Clopidogrel hydrogensulfate, [13C6]-Clopidogrel hydrogensulfate can be used to track the metabolic fate of the drug in vivo. The incorporation of stable isotopes allows for the detection of Clopidogrel hydrogensulfate and its metabolites in biological samples using mass spectrometry techniques. This method provides a non-invasive way to monitor drug levels and metabolism, which can aid in optimizing dosing strategies and identifying potential drug interactions. In summary, [13C6]-Clopidogrel hydrogensulfate is a valuable tool in pharmacokinetic and metabolic studies of Clopidogrel hydrogensulfate. Its usage and chemical information enable researchers to gain a better understanding of how the drug is processed within the body, leading to improved drug efficacy and safety.