Indomethacin 13C6

[13C6]-Indomethacin is a stable isotope labeled version of indomethacin, a non-steroidal anti-inflammatory drug (NSAID) commonly used to treat pain, fever, and inflammation. The stable isotope labeling of the carbon atom in the molecule allows for its detection and tracking through various biological systems, providing insight into the drug's pharmacokinetics and metabolism. The usage of [13C6]-Indomethacin is primarily in pharmacokinetic studies to determine the drug's absorption, distribution, metabolism, and excretion (ADME) properties. The labeled drug can be administered to study subjects and its concentration can be measured in blood, urine, and other tissues over time. This information can be used to optimize dosing regimens and improve drug efficacy and safety. Chemically, [13C6]-Indomethacin is identical to the unlabeled version, with the exception of the stable isotope labeling. It has a molecular weight of 406.47 g/mol and a chemical formula of C22H16ClNO4, containing 6 carbon atoms labeled with the stable isotope carbon-13. The drug works by inhibiting the production of prostaglandins, which are responsible for inflammation and pain. However, like all NSAIDs, it can cause side effects such as gastrointestinal bleeding and kidney damage in some individuals. Overall, [13C6]-Indomethacin is a valuable tool in pharmacological research for understanding the pharmacokinetics and metabolism of indomethacin and other NSAIDs.