Dehydrofelodipine 13C4

[13C4]-Dehydrofelodipine is a labeled compound that is used primarily in pharmacokinetic and pharmacodynamic studies. It is a derivative of felodipine, which is a calcium channel blocker used to treat hypertension and angina pectoris. The compound is labeled with 13C at four carbon atoms, which allows for the tracking of the drug in vivo using mass spectrometry. The labeled compound is synthesized using stable isotope labeling techniques, which incorporate the 13C label into the carbon atoms of the drug molecule. This makes it possible to distinguish the labeled compound from the unlabeled drug in biological samples. The labeled compound can be administered to animals or human subjects, and its pharmacokinetics can be studied using mass spectrometry to determine its absorption, distribution, metabolism, and excretion. The chemical structure of [13C4]-Dehydrofelodipine is similar to that of felodipine, with the addition of the 13C label. The compound has a molecular weight of 394.5 g/mol and a melting point of 153-155°C. It is a white to off-white powder that is soluble in organic solvents such as ethanol and methanol. In conclusion, [13C4]-Dehydrofelodipine is a valuable tool for pharmacokinetic and pharmacodynamic studies, allowing for the tracking of felodipine in vivo using mass spectrometry. Its stable isotope labeling also ensures that the drug can be distinguished from endogenous compounds in biological samples.