[13C5]-Ribavirin

[13C5]-Ribavirin is a stable isotope labeled version of the antiviral drug ribavirin. Ribavirin is a synthetic nucleoside analog and is used in combination with other drugs to treat chronic hepatitis C virus (HCV) infection. The [13C5]-Ribavirin has the same chemical structure as the non-labeled ribavirin except that five carbon atoms have been replaced with their stable isotopes. The isotope labeling makes the drug useful for pharmacokinetic studies, metabolic profiling, and drug interaction studies. The mechanism of action of ribavirin is not completely understood. It is believed to inhibit viral replication by interfering with the synthesis of viral RNA. Ribavirin has also been shown to enhance the host immune response against the virus. The drug is taken orally and is metabolized in the liver. The labeled carbon atoms in [13C5]-Ribavirin do not affect the pharmacokinetic properties or the therapeutic efficacy of the drug. Ribavirin has several side effects including anemia, fatigue, nausea, and rash. The drug is contraindicated in pregnant women due to the risk of birth defects. Patients taking ribavirin should be closely monitored for any signs of anemia and liver function abnormalities. Overall, [13C5]-Ribavirin is a valuable tool for studying the pharmacokinetics and metabolism of ribavirin and for investigating drug-drug interactions.