Fosaprepitant dimeglumine 13C6
| Chemical Name | Fosaprepitant dimeglumine 13C6 |
|---|---|
| Alternate Names | Aprepitant Stable Isotopes, Stable Isotopes of Aprepitant |
| CAT No. | CS-EK-01820 |
| CAS Registry# | 265121-04-8 unlabeled |
| Category | Stable Isotopes |
| Stock | Enquire |
| Mol. Wt. | Not Available |
| Mol. For. | Not Available |
| Hazardous | This is not a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Aprepitant |
| Canonical Smiles | CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC2C(N(CCO2)CC3=NN(C(=O)N3)P(=O)(O)O)C4=CC=C(C=C4)F.CNCC(C(C(C(CO)O)O)O)O.CNCC(C(C(C(CO)O)O)O)O |
| InchIKey | VRQHBYGYXDWZDL-OOZCZQCLSA-N |
| Inchl | InChI=1S/C23H22F7N4O6P.2C7H17NO5/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)40-20-19(13-2-4-17(24)5-3-13)33(6-7-39-20)11-18-31-21(35)34(32-18)41(36,37)38;2*1-8-2-4(10)6(12)7(13)5(11)3-9/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H,31,32,35)(H2,36,37,38);2*4-13H,2-3H2,1H3/t12-,19+,20-;2*4-,5+,6+,7+/m100/s1 |
| IUPAC | [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-5-oxo-4H-1,2,4-triazol-1-yl]phosphonic acid;(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol |
| Controlled | No |
| Shipping | Free for purchase above 200$ |
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| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
[13C6]-Fosaprepitant dimeglumine is a chemical compound used in the treatment of chemotherapy-induced nausea and vomiting. It is a prodrug of aprepitant and is administered intravenously. The compound is a highly selective antagonist of the neurokinin-1 (NK1) receptor, which is responsible for the regulation of emesis.
The addition of 13C6 to the chemical structure of fosaprepitant dimeglumine allows for better detection and quantification of the drug in biological samples. This is particularly useful in pharmacokinetic studies where the metabolism and elimination of the drug can be tracked.
In terms of the chemical properties of [13C6]-Fosaprepitant dimeglumine, it is a water-soluble, crystalline powder with a molecular weight of 1002.21 g/mol. It is composed of 6 carbon atoms that have been labeled with the stable isotope 13C, which has a natural abundance of 1.1%. The dimeglumine salt form of the compound enhances its solubility and stability.
Overall, [13C6]-Fosaprepitant dimeglumine is a valuable tool for pharmacokinetic studies and a promising treatment option for chemotherapy-induced nausea and vomiting.
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Related Compounds
Aprepitant intermediate D4 | Fosaprepitant D4 | Fosaprepitant D4 Dimeglumine | Aprepitant-13C2,d2 (Major) | Aprepitant D4 | rac-Aprepitant-D4 | Aprepitant benzyl intermediate D4 |