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Product Information

Product [13C6]-o-Hydroxyatorvastatin
CAT No. CS-EK-01949
CAS No. 214217-86-4unlabeled
Status price
Category Stable Isotopes
Hazardous Hazard
Purity Not less than 90%
Controlled No

Product Description

[13C6]-o-Hydroxyatorvastatin is a stable isotopic-labeled form of the cholesterol-lowering medication atorvastatin. This compound is used in pharmacokinetic studies to assess the absorption, distribution, metabolism, and excretion of atorvastatin in vivo. By adding six carbon-13 atoms to o-Hydroxyatorvastatin, researchers can track the compound's movement through the body using techniques such as mass spectrometry. Atorvastatin is a member of the statin drug class, which inhibits the enzyme HMG-CoA reductase to lower cholesterol levels in the blood. It is prescribed to prevent cardiovascular disease in patients with high cholesterol. o-Hydroxyatorvastatin is a metabolite of atorvastatin that is produced in the liver and excreted in the urine. By labeling o-Hydroxyatorvastatin with carbon-13, researchers can distinguish it from other metabolites and assess its pharmacokinetics in vivo. Chemically, [13C6]-o-Hydroxyatorvastatin has a molecular formula of C33H37[13C6]NO5 and a molecular weight of 579.66 g/mol. It is a white to off-white powder that is soluble in methanol and ethanol. The labeled compound is stable under normal storage conditions and can be stored at -20°C until use. In conclusion, [13C6]-o-Hydroxyatorvastatin is an important tool for pharmacokinetic studies of atorvastatin. Its chemical properties and stable isotopic labeling make it a valuable tool for researchers studying the metabolism and distribution of atorvastatin in vivo.

Additional Information

Packing Product will be supplied in Vials, in certain conditions we also use 'Septa Vials'
Controlled No
Parent API Atorvastatin
Canonical Smiles CC(C)C1=C(C(=C(N1CCC(CC(CC(=O)O)O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4O
Inchl InChI=1S/C33H35FN2O6/c1-20(2)31-30(33(42)35-26-10-6-7-11-27(26)39)29(21-8-4-3-5-9-21)32(22-12-14-23(34)15-13-22)36(31)17-16-24(37)18-25(38)19-28(40)41/h3-15,20,24-25,37-39H,16-19H2,1-2H3,(H,35,42)(H,40,41)/t24-,25-/m1/s1
IUPAC (3R,5R)-7-[2-(4-fluorophenyl)-4-[(2-hydroxyphenyl)carbamoyl]-3-phenyl-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid
Hazardous No

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Safety & Handling Information

General Information Use proper personal protective equipment
Handling Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Engineering Control Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels.
Clothing Wear appropriate protective clothing to minimize contact with skin.
Skin Wear appropriate protective gloves and clothing to prevent skin exposure.
Eyes Wear safety glasses and chemical goggles if splashing is possible.
Inhalation Remove from exposure and move to fresh air immediately.

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Sample Label

logo [13C6]-o-Hydroxyator... www.clearsynth.com 
 CAT : CS-EK-01949 BATCH : CSC-WWW0757

 MF: --
 CAS: 214217-86-4unlabeled
 Date of Anaysis: 19-Aug-2023
 Retest Date: 19-Jun-2026
MW: --

Store at refrigerator (2-8C)
Qty: 60 MG 
 Only for R & D and Analytical purpose, Not for Human Consumption.

Sample Packaging

Sample Packaging

Sample Vials

Sample Vials
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