[13C6]-o-Hydroxyatorvastatin

[13C6]-o-Hydroxyatorvastatin is a stable isotopic-labeled form of the cholesterol-lowering medication atorvastatin. This compound is used in pharmacokinetic studies to assess the absorption, distribution, metabolism, and excretion of atorvastatin in vivo. By adding six carbon-13 atoms to o-Hydroxyatorvastatin, researchers can track the compound's movement through the body using techniques such as mass spectrometry. Atorvastatin is a member of the statin drug class, which inhibits the enzyme HMG-CoA reductase to lower cholesterol levels in the blood. It is prescribed to prevent cardiovascular disease in patients with high cholesterol. o-Hydroxyatorvastatin is a metabolite of atorvastatin that is produced in the liver and excreted in the urine. By labeling o-Hydroxyatorvastatin with carbon-13, researchers can distinguish it from other metabolites and assess its pharmacokinetics in vivo. Chemically, [13C6]-o-Hydroxyatorvastatin has a molecular formula of C33H37[13C6]NO5 and a molecular weight of 579.66 g/mol. It is a white to off-white powder that is soluble in methanol and ethanol. The labeled compound is stable under normal storage conditions and can be stored at -20°C until use. In conclusion, [13C6]-o-Hydroxyatorvastatin is an important tool for pharmacokinetic studies of atorvastatin. Its chemical properties and stable isotopic labeling make it a valuable tool for researchers studying the metabolism and distribution of atorvastatin in vivo.