Vandetanib 13C6

[13C6]-Vandetanib is a stable isotope labeled vandetanib, which is a potent inhibitor of vascular endothelial growth factor receptor (VEGFR), epidermal growth factor receptor (EGFR), and RET tyrosine kinase. The addition of six carbon-13 atoms to the vandetanib molecule allows researchers to track and identify the compound during various in vivo and in vitro experiments. [13C6]-Vandetanib is typically used in pharmacokinetic studies to determine the bioavailability, distribution, metabolism, and elimination of the drug. Researchers can analyze the isotopic labeling of [13C6]-Vandetanib in various tissues and bodily fluids to determine the drug's pharmacokinetics and pharmacodynamics. This information can help optimize dosing regimens and identify potential drug interactions. In terms of chemical information, [13C6]-Vandetanib has a molecular formula of C22H14C6F3N4O3S and a molecular weight of 608.57 g/mol. The compound has a melting point of approximately 227-229°C and is soluble in dimethyl sulfoxide, ethanol, and methanol. Overall, [13C6]-Vandetanib is a useful tool for researchers studying the pharmacokinetics and pharmacodynamics of vandetanib and its effects on various signaling pathways. Its isotopic labeling allows for accurate tracking and identification of the drug in biological systems, providing valuable insights into its behavior and potential therapeutic applications.