[13C6]-p-Aminohippuric acid

[13C6]-p-Aminohippuric acid is a stable isotope-labeled derivative of p-Aminohippuric acid (PAH), a small organic molecule that is commonly used in medical research to measure renal plasma flow. PAH is an anionic compound that is rapidly cleared from the bloodstream by the kidneys and excreted into the urine. By measuring the rate at which PAH is cleared from the plasma, researchers can estimate the rate of blood flow through the kidneys, which is an important parameter for evaluating kidney function. The stable isotope-labeled derivative [13C6]-p-Aminohippuric acid is used in mass spectrometry-based experiments to quantify the levels of PAH in biological samples. The incorporation of six carbon-13 atoms into the molecule allows researchers to distinguish between the labeled and unlabeled forms of PAH, providing greater accuracy and precision in quantification. In addition, the stable isotope-labeled derivative can be used as an internal standard for calibration and normalization of analytical measurements. The chemical formula of [13C6]-p-Aminohippuric acid is C9H9N2O3S, and its molecular weight is 247.25 g/mol. It is a white to off-white crystalline powder that is soluble in water and ethanol. The compound is stable under normal laboratory conditions and can be stored for extended periods of time if kept dry and protected from light. [13C6]-p-Aminohippuric acid is commercially available from several chemical suppliers and is commonly used in biomedical research and clinical diagnostics.