Nifedipine 13C8

[13C8]-Nifedipine is a labeled version of the drug nifedipine that has been synthesized with eight carbon-13 atoms incorporated into its molecular structure. This labeling allows for the tracking and identification of the drug in biological systems using various analytical techniques, such as nuclear magnetic resonance (NMR) spectroscopy. Nifedipine is a calcium channel blocker that is commonly used in the treatment of hypertension and angina. It inhibits the influx of calcium ions into smooth muscle cells, causing relaxation and vasodilation of blood vessels. This leads to a decrease in blood pressure and an increase in blood flow to the heart. The incorporation of carbon-13 atoms into the nifedipine molecule provides valuable information about its metabolic fate and distribution in the body. For example, by administering [13C8]-nifedipine to a patient and analyzing their urine or blood samples, researchers can determine the drug's pharmacokinetics, including its absorption, distribution, metabolism, and excretion. Additionally, [13C8]-nifedipine can be used as a tracer in drug development studies, allowing researchers to monitor the fate of the drug in preclinical and clinical trials. This information can help inform dosing regimens and improve drug efficacy and safety. Overall, [13C8]-nifedipine is a valuable tool in pharmaceutical research and development, providing critical information about the pharmacokinetics and metabolism of nifedipine and other drugs in the same class.