[13C3]-Perindoprilat

[13C3]-Perindoprilat is a stable-labeled isotopic form of the active metabolite of perindopril, a long-acting angiotensin-converting enzyme (ACE) inhibitor used in the treatment of hypertension and heart failure. The stable-labeling of the compound allows for its accurate detection and quantification in biological samples, making it a valuable tool for pharmacokinetic and pharmacodynamic studies. As an ACE inhibitor, perindoprilat works by blocking the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor that increases blood pressure, and by enhancing the activity of bradykinin, a vasodilator that lowers blood pressure. The stable-labeled isotopic form of perindoprilat is commonly used in studies aimed at investigating the pharmacokinetics and metabolism of perindopril and its active metabolite in humans and animals. The chemical formula of [13C3]-Perindoprilat is C16H22N2O4, with a molecular weight of 306.36 g/mol. The compound is a white to off-white powder that is soluble in water, dimethyl sulfoxide (DMSO), and methanol. Its purity is typically greater than 98% and it is stable under normal storage conditions. In summary, [13C3]-Perindoprilat is a useful tool for investigating the pharmacokinetics and metabolism of perindopril and its active metabolite. Its stable labeling allows for accurate detection and quantification in biological samples, making it a valuable resource for drug development and clinical research.