Amphotericin B 13C6

[13C6]-Amphotericin B is a stable isotope-labeled form of the antifungal drug Amphotericin B. It is used in various research applications to study the pharmacokinetics, metabolism, and efficacy of Amphotericin B in vivo. This labeled compound is a useful tool for tracing the fate of Amphotericin B in the body and quantifying its distribution and elimination. Amphotericin B is a polyene macrolide antibiotic that binds to ergosterol, a component of fungal cell membranes, and disrupts their structure and function. The labeled version of the drug, [13C6]-Amphotericin B, contains six carbon atoms that are replaced with the heavier carbon-13 isotope, which does not alter the drug's chemical properties but enables its detection and quantification using mass spectrometry. The chemical formula of [13C6]-Amphotericin B is C47H73NO17, and its molecular weight is 924.1 g/mol. The compound is a yellowish powder that is soluble in dimethyl sulfoxide (DMSO) or methanol but practically insoluble in water. The recommended storage temperature for [13C6]-Amphotericin B is -20°C, and it should be protected from light and moisture. Overall, [13C6]-Amphotericin B is a valuable tool for investigating the pharmacology and pharmacokinetics of Amphotericin B, which is a critical drug for treating life-threatening fungal infections. Its use in research can provide insights into drug efficacy, toxicity, and drug-drug interactions, which can ultimately lead to better treatment strategies for fungal infections.