1-((R)-3-(4-Amino-3-(4-(phenoxy-D5)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2,3-dihydroxypropan-1-one

1-((R)-3-(4-Amino-3-(4-(phenoxy-D5)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2,3-dihydroxypropan-1-one is a chemical compound that belongs to the class of pyrazolopyrimidine derivatives. It is a potent inhibitor of a protein called cyclin-dependent kinase 4 (CDK4), which plays a crucial role in cell cycle regulation and proliferation. This compound is being studied for its potential use as a therapeutic agent in the treatment of cancer. CDK4 inhibitors have been shown to be effective in preventing the growth of cancer cells by blocking their ability to divide and multiply. This makes them a promising target for cancer therapy. In addition to its CDK4 inhibitory activity, this compound also exhibits good oral bioavailability and pharmacokinetic properties, which make it a promising drug candidate for further development. The chemical formula of 1-((R)-3-(4-Amino-3-(4-(phenoxy-D5)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2,3-dihydroxypropan-1-one is C26H28D5N7O4. Its molecular weight is 522.63 g/mol. The compound has a melting point of approximately 225-227°C and a solubility of 2.5 mg/mL in water. Its chemical structure consists of a pyrazolopyrimidine core, a piperidine ring, and a dihydroxypropanone moiety.