[13C5]-Azacitidine

[13C5]-Azacitidine is a stable isotope-labeled form of the drug Azacitidine, which is used for the treatment of myelodysplastic syndrome, a group of disorders in which the bone marrow fails to produce enough healthy blood cells. Azacitidine is a nucleoside analog that incorporates into DNA and RNA, leading to inhibition of DNA methyltransferase and inducing apoptosis of abnormal cells. [13C5]-Azacitidine is commonly used in clinical research to study the metabolism, pharmacokinetics, and pharmacodynamics of Azacitidine. It is a valuable tool for understanding the mechanism of action of Azacitidine and for developing more effective treatment strategies for myelodysplastic syndrome. The chemical formula of [13C5]-Azacitidine is C11H15N5O4, with a molecular weight of 293.27 g/mol. It contains five stable carbon-13 isotopes, which can be detected and quantified using mass spectrometry. The isotopic labeling does not affect the pharmacological properties of Azacitidine, but it allows for more accurate and sensitive analysis of drug concentrations in biological samples. Overall, [13C5]-Azacitidine is a valuable tool for researchers and clinicians seeking to better understand and treat myelodysplastic syndrome. Its stable isotopic labeling provides a powerful means of studying the pharmacokinetics and pharmacodynamics of Azacitidine, which can lead to improved treatment outcomes for patients.