Abacavir-d4 HCl
| Product Name | Abacavir-d4 HCl |
|---|---|
| Alternate Names | Abacavir Stable Isotopes, Stable Isotopes of Abacavir |
| CAT No. | CS-EV-00001 |
| CAS No. | 1260619-56-4 (Freebase) |
| Category | Stable Isotopes |
| Stock | IN-Stock |
| Mol. Wt. | 326.82 g/mol |
| Mol. For. | C₁₄H₁₅D₄ClN₆O |
| Hazardous | This is not a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Abacavir |
| Smileys | C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)C4CC(C=C4)CO |
| Canonical Smiles | C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)C4CC(C=C4)CO |
| InchIKey | MCGSCOLBFJQGHM-ZOTQTBSBSA-N |
| Inchl | InChI=1S/C14H18N6O/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19)/t8-,10+/m1/s1/i2D2,3D2 |
| IUPAC | [(1S,4R)-4-[2-amino-6-[(2,2,3,3-tetradeuteriocyclopropyl)amino]purin-9-yl]cyclopent-2-en-1-yl]methanol |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
Abacavir-d4 HCl is a modified form of the anti-viral drug Abacavir, which is used in the treatment of HIV-1 infection. The abbreviation “d4” indicates that the compound contains four deuterium atoms, which are heavy isotopes of hydrogen. This modification is made to Abacavir in order to create a stable isotope-labeled version of the drug, which can be used in pharmacokinetic studies to understand its metabolism and excretion.
Abacavir-d4 HCl is administered orally in the form of tablets, which are taken with or without food. The recommended adult dose is 600 mg daily, divided into two or three doses. The drug is absorbed rapidly from the gastrointestinal tract and reaches peak plasma concentrations within 1.5 hours. It is metabolized in the liver and excreted in the urine and feces.
The exact mechanism of action of Abacavir-d4 HCl is not fully understood, but it is thought to inhibit the activity of the reverse transcriptase enzyme, which is essential for the replication of the HIV virus. The drug is also known to have a low genetic barrier to resistance, meaning that HIV can quickly develop resistance to Abacavir-d4 HCl if it is not used in combination with other anti-retroviral drugs.
In terms of chemical information, Abacavir-d4 HCl has the molecular formula C14H13D4N5O3·HCl and a molecular weight of 342.82 g/mol. It is a white to off-white crystalline powder that is highly soluble in water and slightly soluble in ethanol. The drug should be stored in a cool, dry place and protected from light.
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Related Compounds
abacavir D5 | Abacavir D4 | Abacavir-d4 5’-4-Chloro-6-methylpyrimidine-2,5-diamine | trans-Abacavir-d4 Hydrochloride |