Product Name |
(R)-Cinacalcet-D3 Hydrochloride |
Alternate Names |
Cinacalcet Stable Isotopes, Stable Isotopes of Cinacalcet |
CAT No. |
CS-F-00068
|
CAS No. |
364782-34-3 (unlabelled) |
Category |
Stable Isotopes |
Stock |
Enquire
|
Mol. Wt. |
396.89 g/mol |
Mol. For. |
C22H20D3ClF3N
|
Hazardous |
This is not a Hazardous Compound
|
COA |
View Sample COA
|
MSDS |
View Sample MSDS
|
Parent API |
Cinacalcet |
Controlled |
No |
Shipping |
Free for purchase above 1000$ |
Delivery |
In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
Return |
Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
Ordering |
Place your order online or by email sales@clearsynth.com |
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(R)-Cinacalcet-D3 Hydrochloride is a chemical compound that is used as a medication for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease. It is a synthetic analog of calcimimetic cinacalcet that has been deuterated to enhance its stability and efficacy. The compound works by binding to the calcium-sensing receptor on the parathyroid gland, which regulates the secretion of parathyroid hormone (PTH). This results in a decrease in the secretion of PTH, which in turn reduces the levels of calcium and phosphorus in the blood.
The chemical formula of (R)-Cinacalcet-D3 Hydrochloride is C22H19D3ClF2N, and its molecular weight is 370.90 g/mol. It is an off-white to pale yellow crystalline powder that is sparingly soluble in water and soluble in methanol and ethanol. The compound is typically administered as an oral tablet, with a recommended starting dose of 30 mg once daily. The dose may be adjusted based on the patient's response and serum calcium levels.
(R)-Cinacalcet-D3 Hydrochloride is metabolized in the liver and excreted in the feces and urine. It is primarily metabolized by cytochrome P450 enzymes, particularly CYP3A4 and CYP2D6. The half-life of the compound is approximately 30-40 hours, and it takes about 5-7 days to reach steady-state concentrations in the blood.
Overall, (R)-Cinacalcet-D3 Hydrochloride is an effective medication for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease. Its deuterated analog enhances its stability and efficacy, making it a valuable addition to the armamentarium of treatments for this condition.