3-Deoxy Chlorthalidone-D4

3-Deoxy Chlorthalidone-D4 is a deuterium-labeled analog of the diuretic drug Chlorthalidone. It is primarily used in pharmaceutical research as a reference standard or internal standard for pharmacokinetic and bioanalytical studies. Chlorthalidone is a thiazide-like diuretic that works by inhibiting the reabsorption of sodium and chloride ions in the distal convoluted tubule of the kidney, leading to increased urine output and decreased blood volume. The deuterium-labeled 3-Deoxy Chlorthalidone-D4 has the same chemical structure as the parent drug, but with four deuterium atoms incorporated into the molecule. The incorporation of deuterium into the molecule allows for more precise and accurate analysis of Chlorthalidone in biological samples using techniques such as liquid chromatography-mass spectrometry (LC-MS) or gas chromatography-mass spectrometry (GC-MS). Additionally, deuterium-labeled internal standards are useful for correcting for matrix effects and ensuring reliable quantification of the parent drug in complex biological matrices such as blood or urine. Overall, the use of 3-Deoxy Chlorthalidone-D4 as a reference standard or internal standard can aid in the development and validation of analytical methods for the quantification of Chlorthalidone and other related compounds in biological samples, ultimately improving our understanding of their pharmacokinetics and potential therapeutic applications.