Allotetrahydrocortisone-[D4]

Allotetrahydrocortisone-[D4], also known as Tetrahydrocortisone-d4, is a stable isotopic labeled form of cortisol, a hormone that is produced by the adrenal gland. This compound is used in research and clinical applications as a tracer in metabolic and pharmacokinetic studies. It is also used as a diagnostic tool for disorders related to cortisol metabolism. Allotetrahydrocortisone-[D4] is a white to off-white crystalline powder that is soluble in water and ethanol. It is stable under normal conditions of use and storage. This compound has a molecular weight of 363.6 g/mol and a chemical formula of C21H27D4O5. The addition of deuterium atoms at specific positions in the molecule allows for the tracking of the compound's metabolism and distribution in the body. This helps in understanding the pharmacokinetics and pharmacodynamics of cortisol and its derivatives. The use of isotopic labeling also provides a more accurate measurement of the compound's concentration in biological samples. Allotetrahydrocortisone-[D4] is typically administered intravenously or orally, depending on the study design. The compound is well-tolerated in humans, with no significant adverse effects reported at therapeutic doses. However, caution should be exercised when using this compound in patients with known allergies or hypersensitivity to cortisol or its derivatives. In summary, Allotetrahydrocortisone-[D4] is a valuable tool in research and clinical applications for understanding cortisol metabolism and related disorders. Its stable isotopic labeling provides a reliable and accurate measurement of the compound's concentration in biological samples.