17β-Estradiol-13C3 Undecanoate

17β-Estradiol-13C3 Undecanoate is a synthetic estrogen that is used primarily in hormone replacement therapy. It is a modified form of natural estrogen, 17β-estradiol, with an undecanoate ester attached to the 17β-position. This modification allows for slower release of the hormone, providing sustained levels of estrogen in the body. Estrogen is a sex hormone that plays a critical role in the development and maintenance of female reproductive tissues and secondary sex characteristics. It also has important effects on bone health, cardiovascular health, and cognitive function. In hormone replacement therapy, 17β-Estradiol-13C3 Undecanoate is used to alleviate symptoms of menopause, such as hot flashes, vaginal dryness and mood swings. It can also be used to prevent osteoporosis, a condition where bones become weak and fragile. Chemically, 17β-Estradiol-13C3 Undecanoate is a stable isotopic analogue of 17β-estradiol. The three carbon atoms in the ester group are replaced with the stable isotope carbon-13. This modification allows for the tracking of the drug in biological systems using mass spectrometry. The undecanoate ester group is hydrolyzed by esterases in the body, releasing the active hormone. In conclusion, 17β-Estradiol-13C3 Undecanoate is a synthetic estrogen used in hormone replacement therapy to alleviate symptoms of menopause and prevent osteoporosis. Its chemical modification allows for sustained release and tracking in biological systems.