18-Hydroxycortisol-[9,11,12,12-d4]

18-Hydroxycortisol-[9,11,12,12-d4] is a stable isotope-labeled derivative of 18-hydroxycortisol (18-OHF). 18-OHF is a steroid hormone produced by the adrenal gland and is used as a biomarker for assessing the activity of the adrenal cortex. It is also used in the diagnosis of disorders related to adrenal gland function, including Cushing's syndrome, congenital adrenal hyperplasia, and primary aldosteronism. 18-Hydroxycortisol-[9,11,12,12-d4] is used in clinical research to study the metabolism and pharmacokinetics of 18-OHF. It is also used in the development and validation of analytical methods for the quantification of 18-OHF in biological samples. The chemical formula of 18-Hydroxycortisol-[9,11,12,12-d4] is C21H27D4O5, and its molecular weight is 377.47 g/mol. It is a white to off-white powder that is soluble in organic solvents like methanol, ethanol, and acetone. The compound has a melting point of 245-247 °C. In conclusion, 18-Hydroxycortisol-[9,11,12,12-d4] is a useful tool in clinical research for studying adrenal gland function and developing analytical methods for biomarker quantification. Its stable isotope-labeled structure allows for accurate and precise analysis of 18-OHF in biological samples, leading to improved diagnosis and treatment of adrenal-related disorders.