Abrine-[d3]

Abrine-[d3] is a stable isotopically labeled form of abrine, a toxic protein found in the seeds of plants of the genus Abrus. It is a potent ribosome-inactivating protein that inhibits protein synthesis by irreversibly binding to the ribosome. Abrine-[d3] is a useful tool in the study of protein synthesis and the mechanism of action of ribosome-inactivating proteins. The chemical formula of Abrine-[d3] is C₆₀H₈₄N₁₄O₂₂S₃, and its molecular weight is 1453.98 g/mol. It is synthesized by introducing three deuterium atoms into abrine, which replace three hydrogen atoms. This results in a slight increase in the molecular weight of the compound, making it distinguishable from non-labeled abrine. Abrine-[d3] is typically used as a reference standard in mass spectrometry-based assays, where it is used to quantify the levels of abrine in biological samples. It is also used in pharmacokinetic studies to determine the absorption, distribution, metabolism, and excretion of abrine in vivo. While abrine is a highly toxic substance, Abrine-[d3] is relatively safe to handle when proper precautions are taken. It should be stored in a cool, dry place away from light and moisture, and handled only by trained professionals wearing appropriate protective equipment. In case of accidental exposure, immediate medical attention should be sought.