Dihydroartemisinin
| Chemical Name | Dihydroartemisinin |
|---|---|
| Alternate Names | Artemisinin Impurities, Impurities of Artemisinin |
| CAT No. | CS-O-00576 |
| CAS Registry# | 71939-50-9 |
| Category | Impurities |
| Stock | IN-Stock |
| Mol. Wt. | 284.35 g/mol |
| Mol. For. | C₁₅H₂₄O₅ |
| Hazardous | This is a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Artemisinin |
| Purity | Not less than 90 % |
| Smileys | C[C@@H]1[C@@](CC[C@@H](C)[C@]2([H])CC[C@]3(C)O4)([H])[C@@]2(OO3)[C@]4([H])O[C@@H]1O |
| Canonical Smiles | CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)O)C |
| InchIKey | BJDCWCLMFKKGEE-ISOSDAIHSA-N |
| Inchl | InChI=1S/C15H24O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12+,13-,14-,15-/m1/s1 |
| IUPAC | (1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
Dihydroartemisinin (DHA) is a semisynthetic derivative of artemisinin, a natural product isolated from the plant Artemisia annua. DHA is widely used as an antimalarial drug due to its potent activity against Plasmodium falciparum, the parasite responsible for causing severe malaria. It has been included in combination therapies such as artemether-lumefantrine and artesunate-amodiaquine for the treatment of uncomplicated malaria. DHA is also effective against drug-resistant strains of Plasmodium falciparum, making it an important tool in the fight against malaria.
The mechanism of action of DHA involves the formation of free radicals that damage the parasite's cell membrane, leading to its death. Unlike other antimalarial drugs, DHA has a short half-life, which reduces the risk of parasite resistance. DHA is rapidly metabolized in the liver to its active metabolite, dihydroartemisinin-13-glucuronide, which is excreted in the urine.
Apart from its antimalarial activity, DHA has been shown to have potential anticancer and anti-inflammatory effects. It has been investigated as a treatment for a variety of cancers, including leukemia, breast cancer, and lung cancer, and has shown promising results in preclinical studies. DHA has also been shown to reduce inflammation in animal models of inflammatory bowel disease and rheumatoid arthritis.
Overall, DHA is an important drug in the fight against malaria and has potential for the treatment of other diseases. Its chemical properties and mechanism of action make it a valuable tool for researchers and healthcare professionals.
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Related Compounds
Dihydroartemisinin Impurity F | Dihydroartemisinin impurity B | N-(2-Hydroxyethyl)-11-azaartemisinin | Deoxydihydroartemisinin (α,β Mixture) | Dihydro Artemisinin Dimer | Dihydroartemisinin Impuirty I | N-Hydroxy-11-azaartemisinin | Anhydro Dihydro Artemisinin | Artemisinin Impurity 1 (Sodium salt) | Dihydroartemisinin (mixture of alpha and beta isomers) | Dihydro Artemisinin Tetrahydrofuran Acetate | N-Amino-11-azaartemisinin |