Sirolimus D3
| Product Name | Sirolimus D3 |
|---|---|
| CAT No. | CS-O-02669 |
| CAS No. | 392711-19-2 |
| Category | Stable Isotopes |
| Stock | IN-Stock |
| Mol. Wt. | 917.19 g/mol |
| Mol. For. | C₅₁H₇₆D₃NO₁₃ |
| Hazardous | This is a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Purity | Not less than 90 % |
| Therapeutic | Immunosuppressants |
| Smileys | O=C(C([C@](O[C@]1([H])C[C@@H](/C(C)=C/C=C/C=C/[C@H]2C)OC([2H])([2H])[2H])([C@@H](CC1)C)O)=O)N(CCCC3)[C@]3([H])C(O[C@](CC([C@@H](/C=C([C@H]([C@H](C([C@H](C)C2)=O)OC)O)\C)C)=O)([H])[C@H](C)C[C@H](CC[C@H]4O)C[C@H]4OC)=O |
| Canonical Smiles | CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC |
| InchIKey | QFJCIRLUMZQUOT-NWORAYHKSA-N |
| Inchl | InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11-,16-12-,31-17-,35-25-/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1/i8D3 |
| IUPAC | (1R,9S,12S,15R,16Z,18R,19R,21R,23S,24Z,26Z,28Z,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19-methoxy-15,17,21,23,29,35-hexamethyl-30-(trideuteriomethoxy)-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
Sirolimus D3 is a chemical compound that belongs to the class of macrolide immunosuppressants. It is a deuterated form of sirolimus, which is commonly known by its brand name Rapamycin. Sirolimus D3 is used extensively in medical research to study the pharmacokinetics and pharmacodynamics of sirolimus in vivo and in vitro.
Sirolimus D3 is a potent inhibitor of the mammalian target of rapamycin (mTOR) pathway. It binds to the intracellular protein FKBP12 and the resulting complex binds to mTOR, inhibiting its activity. The mTOR pathway plays a crucial role in the regulation of cell growth, proliferation, and survival. By inhibiting this pathway, sirolimus D3 can suppress the immune system and prevent organ rejection in transplant recipients.
In addition to its immunosuppressive properties, sirolimus D3 has also been shown to possess anti-cancer and anti-inflammatory properties. It has been used in the treatment of various types of cancers, including renal cell carcinoma, breast cancer, and lymphoma.
Sirolimus D3 is typically administered orally, and its absorption is not affected by food. It has a half-life of approximately 60 hours, and its metabolism occurs mainly in the liver. The drug is excreted primarily in the feces, with only a small amount excreted in the urine.
Overall, sirolimus D3 is a valuable tool in medical research and has potential therapeutic applications in the treatment of cancer and inflammatory diseases.
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