Pyrazinamide D3

Pyrazinamide D3 is an isotopically labeled form of Pyrazinamide, a drug used to treat tuberculosis. Pyrazinamide D3 is used in research studies to investigate the pharmacokinetics and metabolism of Pyrazinamide in the body. Pyrazinamide works by inhibiting the growth of Mycobacterium tuberculosis, the bacteria that cause tuberculosis. It is often used in combination with other drugs to treat active tuberculosis infections and to prevent the development of drug-resistant strains of the bacteria. Chemically, Pyrazinamide is a pyrazine carboxamide derivative with the molecular formula C5H5N3O. Pyrazinamide D3 has the same chemical structure as Pyrazinamide, but with three deuterium atoms substituted for three hydrogen atoms. This isotopic labeling allows researchers to track the drug's distribution and metabolism in the body using mass spectrometry. Pyrazinamide D3 is typically administered orally as tablets or capsules, and the dosage depends on the patient's weight and the severity of the infection. The drug is metabolized in the liver and excreted in the urine, and its half-life is approximately 9-10 hours. Side effects of Pyrazinamide may include nausea, vomiting, liver toxicity, and joint pain. In conclusion, Pyrazinamide D3 is a valuable tool for researchers studying the pharmacokinetics and metabolism of Pyrazinamide, a drug used to treat tuberculosis. Its isotopic labeling allows for accurate tracking of the drug's distribution and metabolism in the body.